mango leaves

Mangiferin (a polyphenolic ingredient extracted from the stem bark and leaves of Mango tree (Mangifera indica L.) was considered as an antiviral agent upon herpes simplex virus1, HIV and hepatitis B virus2. Zhu XM et al., (1993) studied in vitro effect of mangiferin against Herpes simplex virus (HSV) type 2; mangiferin does not directly inactivate HSV-2 but inhibits the late event in HSV-2 replication2. In in vitro, mangiferin was also able to inhibit HSV-1 virus replication within cells (1) and to antagonize the cytopathic effects of HIV3.

In another in vitro study mangiferin and isomangiferin (also compound found in mango), in antiviral action were found to be effective against HSV-1.4.

Mangoes leaves, stem and bark can be used to make teas, decoctions, and ointments against HSV-1 and HSV-2.

How To Make Mango Leaves Tea

10-12 leaves Fresh mango leaves
2 teaspoons Agave (optional)
300 ml Water

1. Wash mango leaves and chop them into small pieces.
2. Place in a tea infuser and add agave.
3. Pour boiling water over the leaves.
4. Cover and allow it to steep for 15 minutes.
5. Strain (if necessary, pour and drink.


1. Zheng MS, Lu ZY. Antiviral effect of mangiferin and isomangiferin on Heppex simplex virus. Chinese Medical Journal. 1990; 103:160-165.
2. Zhu XM, Song JX, Huang ZZ, Whu YM, Yu MJ. Antiviral activity of mangiferin against herpes simplex virus type 2 in vitro. Zhongguo Yao Li Xue Bao 1993; 14:452-454.
3. Guha S, Ghosal S, Chattopadyay U. Antitumor, immunomodulatory and anti-HIV effect of mangiferin: A naturally occurring glucosylxanthone. Chemotherapy 1996; 42:443-451.
4. Zhongguo Yao Li Xue Bao. 1989 Jan;10(1):85-90. Antiviral effect of mangiferin and isomangiferin on herpes simplex virus –